Marlene Maria Tourais de Barros

Full Professor

PhD in Biochemistry in the specialty of Enzymology and Protein Chemistry at the University of Coimbra (1995) and held in 2007 the “Agregação” in Biology at the University of Aveiro. Professor at the Portuguese Catholic University since 2001.
Director of the Faculty of Dental Medicine (FMD) since 2020 and Director of the Center for Interdisciplinary Research in Health (CIIS) since 2015 (rated Very Good by FCT).
Deputy Director of the Department of Health Sciences from 2010-2015 and Regional Director of the Institute of Health Sciences in Viseu from 2015 until the creation of the FMD.
She coordinated the Master in Molecular Microbiology at the University of Aveiro and the Degree in Biomedical Sciences at Católica.
She was responsible for the scientific and pedagogical coordination of the Basic Sciences curricular units of the Dental Medicine course at UCP.
She taught at the University of Aveiro (1st, 2nd and 3rd cycles) and at the Faculty of Medicine, University of Coimbra (2nd cycle).

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# 10. Identificação na saliva de biomarcadores de suscetibilidade à cárie dentária

Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Carolina Lourenço). 2015. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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# 39. Identificação de biomarcadores salivares de doença periodontal em pacientes com gengivite

Eduardo Esteves, Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Beatriz Patrício Serra). 2015. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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#097. Presença de genes de resistência a antibióticos na cavidade oral: uma revisão sistemática

Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Sara Sousa). 2016. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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#126 Peri‑implantite

Marlene Maria Tourais de Barros (with Rafaela Albino). 2017. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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#145. Proteoma oral humano: da saliva ao diagnóstico das doenças cardiovasculares

Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Rafael Silva). 2016. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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#146. miRNAs salivares como biomarcadores da Diabetes Mellitus tipo II

Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Alexandra Martins). 2016. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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A New Enzyme Available for Peptide Synthesis

Marlene Maria Tourais de Barros (with Barros, M.). 1996. Peptides-european symposium-
Other

A protein profiling strategy for periodontal disease applications

Marlene Maria Tourais de Barros, Nuno Ricardo das Neves Rosa & Gustavo Vicentis de Oliveira Fernandes (with Nuno Rosa). 2019. CED-IADR/NOF - Oral Health Research Congress, Madrid, Spain, 19/09/19
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A saliva como meio auxiliar de diagnóstico das doenças cardiovasculares

Eduardo Esteves, Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Rafael Silva). 2016. 2º Simpósio da Ciência e Tecnologia da Vida e da Saúde
Other

A step forward to implement saliva as diagnostic fluid

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Eduardo Esteves). 2019. 44th FEBS Congress, Krakow, Poland, 6/07/19
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Acetonitrile-induced unfolding of porcine pepsin A. A proposal for a critical role of hydration structures in conformational stability

Marlene Maria Tourais de Barros (with Cardoso, T.). 2009. International Journal of Biological Macromolecules
Book

Activity of cardosins A and B in the presence of organic solvents

Marlene Maria Tourais de Barros (with Sarmento, A.C.). 1998. Progress in Biotechnology
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Algerian cardoon flowers express a large spectrum of coagulant enzymes with potential applications in cheesemaking

Eduardo Esteves, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Abdellah Zikiou). 2020. International Dairy Journal
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Atividade sénior SalivaTec's role

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Biochemical diversity of cardoon flowers (Cynara cardunculus L.)

Marlene Maria Tourais de Barros (with P. Barracosa). 2021. Food Bioscience
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Biomarcadores salivares de pacientes periodontais com diabetes mellitus tipo 2

Marlene Maria Tourais de Barros (with Priscila Paganini Costa).
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CanisOme - The protein signatures of Canis lupus familiaris diseases

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Cardosin A as a model aspartic proteinase for the study of organic solvent effects: An overview on catalytic and structural aspects

Marlene Maria Tourais de Barros (with Sarmento, A.C.). 2003. Journal of Molecular Catalysis B: Enzymatic
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Cardosins A and B, two new enzymes available for peptide synthesis

Marlene Maria Tourais de Barros (with Sarmento, AC). 1998. Journal of Molecular Catalysis B-Enzymatic
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Cardosins applied in neuronal embryonic cell culture: an efficient desegregation tool

Marlene Maria Tourais de Barros (with Duarte, A. S.). 2005. European Journal of Neurology
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Cardosins improve neuronal regeneration after cell disruption: A comparative expression study

Ana Sofia Direito dos Santos Duarte & Marlene Maria Tourais de Barros (with Duarte, A.S.). 2009. Cell Biology and Toxicology
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Cardosins: A new and efficient plant enzymatic tool to dissociate neuronal cells for the establishment of cell cultures

Ana Sofia Direito dos Santos Duarte, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Duarte, A.S.). 2007. Biotechnology and Bioengineering
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Comparasion of hydrolytic activity of cardosin A and B on Collagen i

Ana Sofia Direito dos Santos Duarte & Marlene Maria Tourais de Barros (with Cabrita, A.M.S.). 1997. FASEB Journal
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Computational Approach to Predict Inter-Species Oral Protein-Protein Interactions

Maria José Serol de Brito Correia & Marlene Maria Tourais de Barros (with Correia, Maria). 2013. PROCEEDINGS IWBBIO 2013: INTERNATIONAL WORK-CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING
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Computational prediction of the human-microbial oral interactome

Book

Data Integration Solution for Organ-Specific Studies: An Application for Oral Biology

Maria José Serol de Brito Correia & Marlene Maria Tourais de Barros (with Melo, J.). 2013. Communications in Computer and Information Science
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Diabetic wound treatment with vegetal collagenase?

Eduardo Esteves, Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Eduardo Esteves). 2016. 2º Simpósio da Ciência e Tecnologia da Vida e da Saúde
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Effect of acetonitrile on Cynara cardunculus L. cardosin A stability

Marlene Maria Tourais de Barros (with Shnyrova, A.V.). 2006. International Journal of Biological Macromolecules
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Evaluation of cardosin A as a probe for limited proteolysis in non-aqueous environments - Complex substrates hydrolysis

Ana Sofia Direito dos Santos Duarte & Marlene Maria Tourais de Barros (with Sarmento, A.C.). 2006. Enzyme and Microbial Technology
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Evaluation of cardosin A as a proteolytic probe in the presence of organic solvents

Marlene Maria Tourais de Barros (with Sarmento, A.C.). 2004. Journal of Molecular Catalysis B: Enzymatic
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Evaluation of the specificity of cardosin in peptide synthesis

Marlene Maria Tourais de Barros (with Barros, M.). 1996. FASEB Journal
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Expression of Genes Encoding Extracellular Matrix Macromolecules and Metalloproteinases in Avian Tibial Dyschondroplasia

Marlene Maria Tourais de Barros (with Velada, I.). 2011. Journal of Comparative Pathology
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From the salivary proteome to the OralOme: Comprehensive molecular oral biology

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Functional and conformational changes in the aspartic protease cardosin A induced by TFE

Marlene Maria Tourais de Barros (with Fraga, A.S.). 2012. International Journal of Biological Macromolecules
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Gingipains as a virulence factor in the oral cavity

Maria José Serol de Brito Correia & Marlene Maria Tourais de Barros (with Campos Lopes, P.). 2012. Revista Portuguesa de Estomatologia, Medicina Dentaria e Cirurgia Maxilofacial
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Happiness as a self-state and trait of consciousness: clinical hypnosis and saliva molecular biomarkers - a brief revision.

Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros 2016. Experimental Pathology and Health Sciences. 2016;8 (1): 51-54
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Heterogeneity of a new aspartic proteinase from Cynara cardunculus L.

Marlene Maria Tourais de Barros (with Sarmento, AC). 2005. Febs Journal
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How MMPs regulate avian endochondral ossification

Marlene Maria Tourais de Barros (with Velada, I). 2005. Febs Journal
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I-5. Que proteínas de origem microbiana existem na cavidade oral?

Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Pereira, Maria dos Reis). 2013. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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I-6. Oraloma da Diabetes Melitos tipo 1 e 2 - um estudo comparativo

Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Brás, Vítor Daniel Moreira). 2013. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Other

Identificação de biomarcadores salivares de doença periodontal em pacientes com gengivite

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Immobilisation of cardosin A in chitosan sponges as a novel implant for drug delivery

Ana Sofia Direito dos Santos Duarte & Marlene Maria Tourais de Barros (with Pereira, A.O.). 2005. Current Drug Discovery Technologies
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Influence of saliva interaction on surface properties manufactured for rapid osseointegration in dental implants

Marlene Maria Tourais de Barros (with Marcel F. Kunrath). Biofouling
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Isolation and characterization of a bacteriocin-like peptide produced by Brevibacterium linens ATCC 9172, an orange cheese coryneform bacterium

Marlene Maria Tourais de Barros (with Oliveira, C.). 2002. Peptide Science—Present and Future
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Molecular cognition group strategy

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with J. E. Martins). 2016. 2º Simpósio da Ciência e Tecnologia da Vida e da Saúde, Porto, Portugal, 30/09/16
Other

Molecular highlights in peri-implantitis

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Sofia Mariana Silva). 2016. 2º Simpósio da Ciência e Tecnologia da Vida e da Saúde, Porto, Portugal, 30/09/16
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Morphological evaluation of cardoon (Cynara cardunculus L.): assessing biodiversity for applications based on tradition, innovation and sustainability

Marlene Maria Tourais de Barros (with Barracosa, P.). 2018. Genetic Resources and Crop Evolution
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Multiplicity of aspartic proteinases from Cynara cardunculus L.

Marlene Maria Tourais de Barros (with Sarmento, A.C.). 2009. Planta
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New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach

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Non-native states of cardosin A induced by acetonitrile: Activity modulation via polypeptide chains rearrangements

Marlene Maria Tourais de Barros (with Oliveira, C.S.). 2009. Journal of Molecular Catalysis B: Enzymatic
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On the track for a hypothetical new cardosin?

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with T Cardoso). 2005. FEBS Journal
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Oral microbial proteome: clues of OralCard

Other

Oral microflora and dental caries development among Portuguese children

Nélio Jorge Veiga, Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Sara Sousa). 2016. International Dental Journal
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OralCard: a bioinformatic tool dedicated to the oral cavity system

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OralCard: A bioinformatic tool for the study of oral proteome

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OvinOralOme

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Eduardo Esteves). 2014. Congresso Ciências Veterinárias 2014
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OvinOralOme

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Eduardo Esteves). 2014. Veterinary Sciences Congress 2014, Oeiras, Portugal, 3/04/14
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OvisOme

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Eduardo Esteves). 2016. XXI Meeting of the Portuguese Society of Animal Pathology, Portugal, 20/05/16
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Peptide synthesis catalyzed by Cynara cardunculus L. Acid protease in aqueous-organic biphasic systems

Marlene Maria Tourais de Barros (with Barros, M.T.). 1993. Biotechnology Letters
Other

Peri-implantitis- uncovering the molecular mechanisms by a bioinformatics approach

André Ricardo Maia Correia, Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with André Correia). 2018. Clinical Oral Implants Research
Other

Presença de genes de resistência a antibióticos na cavidade oral

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Sara Sousa). 2016. XXXVI Congresso Anual da Sociedade Portuguesa de Estomatologia e Medicina Dentária, Portugal, 7/10/16
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Protein Quality Assessment on Saliva Samples for Biobanking Purposes

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Reverse hydrolysis by cardosin A: Specificity considerations

Marlene Maria Tourais de Barros (with Sarmento, A.C.). 2004. Journal of Molecular Catalysis B: Enzymatic
Other

SalivaPrint as a Non-invasive Diagnostic Tool

Eduardo Esteves & Marlene Maria Tourais de Barros (with Esteves, Eduardo). 2020. Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies
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SalivaPRINT Toolkit – Protein profile evaluation and phenotype stratification

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SalivaPrint: Sheep Saliva Electrophoretic Protein Profile in a Bioinformatics Approach

Eduardo Esteves, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with E. Esteves). 2018. Journal of Comparative Pathology
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Salivary diagnosis

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with S. Sousa). 2016. 2º Simpósio da Ciência e Tecnologia da Vida e da Saúde, Porto, Portugal, 30/09/16
Other

SalivaTec

Marlene Maria Tourais de Barros & Nuno Ricardo das Neves Rosa (with Nuno Rosa). 2017. xMAP® Connect 2017, Amsterdam, Netherlands, 8/11/17
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Selected Cardoon (Cynara cardunculus L.) Genotypes Suitable for PDO Cheeses in Mediterranean Regions

Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Barracosa, P.). 2018. Chemistry and Biodiversity
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Sialochemical analysis in polytraumatized patients in intensive care units

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Specificity of Cardosins A and B in peptide synthesis

Marlene Maria Tourais de Barros (with Sarmento, AC). 1999. Peptide Science - Present and Future
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Stability performance of Cynara cardunculus L. acid protease in aqueous-organic biphasic systems

Marlene Maria Tourais de Barros (with Barros, M.T.). 1992. Biotechnology Letters
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The characterisation of the collagenolytic activity of cardosin A demonstrates its potential application for extracellular matrix degradative processes

Ana Sofia Direito dos Santos Duarte & Marlene Maria Tourais de Barros (with Duarte, A.S.). 2005. Current Drug Discovery Technologies
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The landscape of protein biomarkers proposed for periodontal disease: Markers with functional meaning

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The role of MMPs in the progression of periodontitis in Portuguese individuals

Marlene Maria Tourais de Barros (with Fraga, AS). 2005. Febs Journal
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Thermostability of cardosin A from Cynara cardunculus L.

Marlene Maria Tourais de Barros (with Pina, D.G.). 2003. Thermochimica Acta
Book

Tracking the functional meaning of the human oral-microbiome protein-protein interactions

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Unfolding of cardosin A in organic solvents and detection of intermediaries

Marlene Maria Tourais de Barros (with Sarmento, A.C.). 2009. Journal of Molecular Catalysis B: Enzymatic
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Web information system for the study of oral health

Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa & Marlene Maria Tourais de Barros (with Melo, J.). 2012. HEALTHINF 2012 - Proceedings of the International Conference on Health Informatics