Raquel Monteiro Marques da Silva

Assistant Researcher

PhD in Biology from the University of Aveiro in 2005, with the study of the molecular mechanisms involved in the evolution of a genetic code alteration.
Was Research Associate in the Population Genetics group from IPATIMUP (2008-2013), working in the dynamics of the NAD metabolic network and its roles in health and disease. These enzymes have been implicated in aging, infection, and are the targets of a novel class of antitumor drugs.
Was Invited Assistant Professor in the Department of Medical Sciences, and researcher in the Bioinformatics group from IEETA and in iBiMED, University of Aveiro (2013-2019). Developed bioinformatics tools to detect genome rearrangements and pathogen signatures, with implications for diagnosis and therapeutics. In collaboration, participates in additional lines of investigation that address the mechanisms of anti-fungal resistance in clinical isolates, and computational methods to predict the impact of human mutations.
Currently Assistant Professor at the Faculty of Dental Medicine, Universidade Católica Portuguesa and researcher in CIIS (Centre for Interdisciplinary Research in Health), in the platform SalivaTec, focused on biomarker research and diagnosis in saliva.

Paper

A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans

Raquel Monteiro Marques da Silva (with Gomes, A.C.). 2007. Genome Biology
Paper

A transcriptomics approach to unveiling the mechanisms of in vitro evolution towards fluconazole resistance of a Candida glabrata Clinical Isolate

Raquel Monteiro Marques da Silva (with Cavalheiro, M.). 2019. Antimicrobial Agents and Chemotherapy
Paper

An alignment-free method to find and visualise rearrangements between pairs of DNA sequences

Raquel Monteiro Marques da Silva (with Pratas, D.). 2015. Scientific Reports
Paper

Comparative context analysis of codon pairs on an ORFeome scale.

Raquel Monteiro Marques da Silva (with Moura, G.). 2005. Genome biology
Paper

Critical roles for a genetic code alteration in the evolution of the genus Candida

Paper

Distribution of Distances Between Symmetric Words in the Human Genome: Analysis of Regular Peaks

Raquel Monteiro Marques da Silva (with Bastos, C.A.C.). 2019. Interdisciplinary Sciences: Computational Life Sciences
Paper

DNA word analysis based on the distribution of the distances between symmetric words

Raquel Monteiro Marques da Silva (with Tavares, A.H.M.P.). 2017. Scientific Reports
Paper

Environmental azole fungicide, prochloraz, can induce cross-resistance to medical triazoles in Candida glabrata

Raquel Monteiro Marques da Silva (with Faria-Ramos, I.). 2014. FEMS Yeast Research
Paper

Epidemiology and susceptibility profile to classic antifungals and over-the-counter products of Malassezia clinical isolates from a Portuguese University Hospital: A prospective study

Raquel Monteiro Marques da Silva (with Pedrosa, A.F.). 2019. Journal of Medical Microbiology
Paper

Essential genetic findings in neurodevelopmental disorders

Raquel Monteiro Marques da Silva (with Cardoso, A.R.). 2019. Human genomics
Paper

Evolution of the genetic code in yeasts

Raquel Monteiro Marques da Silva (with Miranda, I.). 2006. Yeast
Paper

Evolution of the NET (NocA, Nlz, Elbow, TLP-1) protein family in metazoans: Insights from expression data and phylogenetic analysis

Raquel Monteiro Marques da Silva (with Pereira, F.). 2016. Scientific Reports
Paper

Exosomal Aβ-Binding Proteins Identified by “In Silico” Analysis Represent Putative Blood-Derived Biomarker Candidates for Alzheimer´s Disease

Raquel Monteiro Marques da Silva (with Tânia Soares Martins). 2021. International Journal of Molecular Sciences
Paper

Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors

Raquel Monteiro Marques da Silva (with Duarte-Pereira, S.). 2016. Oncotarget
Paper

FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure

Raquel Monteiro Marques da Silva (with e Silva, A.P.). 2020. Scientific Reports
Paper

FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy

Raquel Monteiro Marques da Silva (with Costa-de-Oliveira, S.). 2011. Antimicrobial Agents and Chemotherapy
Paper

Fluconazole and voriconazole resistance in Candida parapsilosis is conferred by gain-of-function mutations in MRR1 transcription factor gene

Raquel Monteiro Marques da Silva (with Branco, J.). 2015. Antimicrobial Agents and Chemotherapy
Paper

Gains, losses and changes of function after gene duplication: Study of the metallothionein family

Raquel Monteiro Marques da Silva (with Moleirinho, A.). 2011. PLoS ONE
Paper

Impact of ERG3 mutations and expression of ergosterol genes controlled by UPC2 and NDT80 in Candida parapsilosis azole resistance

Raquel Monteiro Marques da Silva (with Branco, J.). 2017. Clinical Microbiology and Infection
Paper

Improving the in silico assessment of pathogenicity for compensated variants

Raquel Monteiro Marques da Silva (with Azevedo, L.). 2016. European Journal of Human Genetics
Paper

In vivo and in vitro acquisition of resistance to voriconazole by Candida krusei

Raquel Monteiro Marques da Silva (with Ricardo, E.). 2014. Antimicrobial Agents and Chemotherapy
Paper

Malassezia species retrieved from skin with pityriasis versicolor, seborrhoeic dermatitis and skin free of lesions: a comparison of two sampling methods

Raquel Monteiro Marques da Silva (with Pedrosa, A.F.). 2018. British Journal of Dermatology
Paper

Mechanisms of acquired in vivo and in vitro resistance to voriconazole by Candida krusei following exposure to suboptimal drug concentration

Raquel Monteiro Marques da Silva (with Ricardo, E.). 2020. Antimicrobial Agents and Chemotherapy
Paper

Merging microarray studies to identify a common gene expression signature to several structural heart diseases

Raquel Monteiro Marques da Silva (with Fajarda, O.). 2020. BioData Mining
Paper

Mining clinical attributes of genomic variants through assisted literature curation in Egas

Raquel Monteiro Marques da Silva (with Matos, S.). 2016. Database
Paper

Nampt and Naprt1: Novel polymorphisms and distribution of variants between normal tissues and tumor samples

Raquel Monteiro Marques da Silva (with Duarte-Pereira, S.). 2014. Scientific Reports
Paper

Overview of the interactive task in BioCreative V

Raquel Monteiro Marques da Silva (with Wang, Q.). 2016. Database
Paper

The Evolutionary Portrait of Metazoan NAD Salvage

Raquel Monteiro Marques da Silva (with Carneiro, J.). 2013. PLoS ONE
Paper

The exceptional genomic word symmetry along DNA sequences

Raquel Monteiro Marques da Silva (with Afreixo, V.). 2016. BMC Bioinformatics
Paper

The Role of Recombination in the Origin and Evolution of Alu Subfamilies

Raquel Monteiro Marques da Silva (with Teixeira-Silva, A.). 2013. PLoS ONE
Paper

The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes

Raquel Monteiro Marques da Silva (with Branco, J.). 2021. Virulence
Paper

The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation

Raquel Monteiro Marques da Silva (with Silva, R.M.). 2009. PLoS ONE
Paper

Three minimal sequences found in Ebola virus genomes and absent from human DNA

Raquel Monteiro Marques da Silva (with Silva, R.M.). 2015. Bioinformatics
Book

Tracking the functional meaning of the human oral-microbiome protein-protein interactions

Paper

Transcriptional profiling of azole-resistant Candida parapsilosis strains

Raquel Monteiro Marques da Silva (with Silva, A.P.). 2011. Antimicrobial Agents and Chemotherapy
Paper

Yeast as a model organism for studying the evolution of non-standard genetic codes.

Raquel Monteiro Marques da Silva (with Silva, R.M.). 2004. Briefings in functional genomics & proteomics
Paper

Yeast proteome map (update 2006)

Raquel Monteiro Marques da Silva (with Perrot, M.). 2007. Proteomics