Raquel Monteiro Marques da Silva

Investigador Auxiliar

Generic Bio

Doutorada em Biologia pela Universidade de Aveiro em 2005, com o estudo dos mecanismos moleculares envolvidos na evolução de uma alteração do código genético.
Foi Investigadora Auxiliar do grupo de Genética Populacional do IPATIMUP (2008-2013), onde começou a trabalhar na dinâmica da rede metabólica de NAD e seus papéis na saúde e na doença. Estas enzimas foram implicadas no envelhecimento, infeção e são o alvo de uma nova classe de drogas anti-tumorais.
Foi Professora Auxiliar Convidada do Departamento de Ciências Médicas, e investigadora no grupo de Bioinformática do IEETA e no iBiMED, Universidade de Aveiro (2013-2019). Desenvolveu ferramentas bioinformáticas para detetar rearranjos do genoma e assinaturas de agentes patogénicos, com implicações no diagnóstico e terapêutica. Em colaboração, participa em linhas de investigação sobre os mecanismos de resistência a antifúngicos em isolados clínicos, e em métodos computacionais para prever o impacto de mutações.
Atualmente é Professora Auxiliar na Faculdade de Medicina Dentária da Universidade Católica Portuguesa e investigadora no CIIS (Centro de Investigação Interdisciplinar em Saúde), na plataforma SalivaTec, focada na pesquisa de biomarcadores e diagnóstico em saliva.

Artigo

A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans

Raquel Monteiro Marques da Silva (with Gomes, A.C.). 2007. Genome Biology
Artigo

A transcriptomics approach to unveiling the mechanisms of in vitro evolution towards fluconazole resistance of a Candida glabrata Clinical Isolate

Raquel Monteiro Marques da Silva (with Cavalheiro, M.). 2019. Antimicrobial Agents and Chemotherapy
Artigo

An alignment-free method to find and visualise rearrangements between pairs of DNA sequences

Raquel Monteiro Marques da Silva (with Pratas, D.). 2015. Scientific Reports
Artigo

Comparative context analysis of codon pairs on an ORFeome scale.

Raquel Monteiro Marques da Silva (with Moura, G.). 2005. Genome biology
Artigo

Critical roles for a genetic code alteration in the evolution of the genus Candida

Artigo

Distribution of Distances Between Symmetric Words in the Human Genome: Analysis of Regular Peaks

Raquel Monteiro Marques da Silva (with Bastos, C.A.C.). 2019. Interdisciplinary Sciences: Computational Life Sciences
Artigo

DNA word analysis based on the distribution of the distances between symmetric words

Raquel Monteiro Marques da Silva (with Tavares, A.H.M.P.). 2017. Scientific Reports
Artigo

Environmental azole fungicide, prochloraz, can induce cross-resistance to medical triazoles in Candida glabrata

Raquel Monteiro Marques da Silva (with Faria-Ramos, I.). 2014. FEMS Yeast Research
Artigo

Epidemiology and susceptibility profile to classic antifungals and over-the-counter products of Malassezia clinical isolates from a Portuguese University Hospital: A prospective study

Raquel Monteiro Marques da Silva (with Pedrosa, A.F.). 2019. Journal of Medical Microbiology
Artigo

Essential genetic findings in neurodevelopmental disorders

Raquel Monteiro Marques da Silva (with Cardoso, A.R.). 2019. Human genomics
Artigo

Evolution of the genetic code in yeasts

Raquel Monteiro Marques da Silva (with Miranda, I.). 2006. Yeast
Artigo

Evolution of the NET (NocA, Nlz, Elbow, TLP-1) protein family in metazoans: Insights from expression data and phylogenetic analysis

Raquel Monteiro Marques da Silva (with Pereira, F.). 2016. Scientific Reports
Artigo

Exosomal Aβ-Binding Proteins Identified by “In Silico” Analysis Represent Putative Blood-Derived Biomarker Candidates for Alzheimer´s Disease

Raquel Monteiro Marques da Silva (with Tânia Soares Martins). 2021. International Journal of Molecular Sciences
Artigo

Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors

Raquel Monteiro Marques da Silva (with Duarte-Pereira, S.). 2016. Oncotarget
Artigo

FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure

Raquel Monteiro Marques da Silva (with e Silva, A.P.). 2020. Scientific Reports
Artigo

FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy

Raquel Monteiro Marques da Silva (with Costa-de-Oliveira, S.). 2011. Antimicrobial Agents and Chemotherapy
Artigo

Fluconazole and voriconazole resistance in Candida parapsilosis is conferred by gain-of-function mutations in MRR1 transcription factor gene

Raquel Monteiro Marques da Silva (with Branco, J.). 2015. Antimicrobial Agents and Chemotherapy
Artigo

Gains, losses and changes of function after gene duplication: Study of the metallothionein family

Raquel Monteiro Marques da Silva (with Moleirinho, A.). 2011. PLoS ONE
Artigo

Impact of ERG3 mutations and expression of ergosterol genes controlled by UPC2 and NDT80 in Candida parapsilosis azole resistance

Raquel Monteiro Marques da Silva (with Branco, J.). 2017. Clinical Microbiology and Infection
Artigo

Improving the in silico assessment of pathogenicity for compensated variants

Raquel Monteiro Marques da Silva (with Azevedo, L.). 2016. European Journal of Human Genetics
Artigo

In vivo and in vitro acquisition of resistance to voriconazole by Candida krusei

Raquel Monteiro Marques da Silva (with Ricardo, E.). 2014. Antimicrobial Agents and Chemotherapy
Artigo

Malassezia species retrieved from skin with pityriasis versicolor, seborrhoeic dermatitis and skin free of lesions: a comparison of two sampling methods

Raquel Monteiro Marques da Silva (with Pedrosa, A.F.). 2018. British Journal of Dermatology
Artigo

Mechanisms of acquired in vivo and in vitro resistance to voriconazole by Candida krusei following exposure to suboptimal drug concentration

Raquel Monteiro Marques da Silva (with Ricardo, E.). 2020. Antimicrobial Agents and Chemotherapy
Artigo

Merging microarray studies to identify a common gene expression signature to several structural heart diseases

Raquel Monteiro Marques da Silva (with Fajarda, O.). 2020. BioData Mining
Artigo

Mining clinical attributes of genomic variants through assisted literature curation in Egas

Raquel Monteiro Marques da Silva (with Matos, S.). 2016. Database
Artigo

Nampt and Naprt1: Novel polymorphisms and distribution of variants between normal tissues and tumor samples

Raquel Monteiro Marques da Silva (with Duarte-Pereira, S.). 2014. Scientific Reports
Artigo

Overview of the interactive task in BioCreative V

Raquel Monteiro Marques da Silva (with Wang, Q.). 2016. Database
Artigo

The Evolutionary Portrait of Metazoan NAD Salvage

Raquel Monteiro Marques da Silva (with Carneiro, J.). 2013. PLoS ONE
Artigo

The exceptional genomic word symmetry along DNA sequences

Raquel Monteiro Marques da Silva (with Afreixo, V.). 2016. BMC Bioinformatics
Artigo

The Role of Recombination in the Origin and Evolution of Alu Subfamilies

Raquel Monteiro Marques da Silva (with Teixeira-Silva, A.). 2013. PLoS ONE
Artigo

The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes

Raquel Monteiro Marques da Silva (with Branco, J.). 2021. Virulence
Artigo

The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation

Raquel Monteiro Marques da Silva (with Silva, R.M.). 2009. PLoS ONE
Artigo

Three minimal sequences found in Ebola virus genomes and absent from human DNA

Raquel Monteiro Marques da Silva (with Silva, R.M.). 2015. Bioinformatics
Livro

Tracking the functional meaning of the human oral-microbiome protein-protein interactions

Artigo

Transcriptional profiling of azole-resistant Candida parapsilosis strains

Raquel Monteiro Marques da Silva (with Silva, A.P.). 2011. Antimicrobial Agents and Chemotherapy
Artigo

Yeast as a model organism for studying the evolution of non-standard genetic codes.

Raquel Monteiro Marques da Silva (with Silva, R.M.). 2004. Briefings in functional genomics & proteomics
Artigo

Yeast proteome map (update 2006)

Raquel Monteiro Marques da Silva (with Perrot, M.). 2007. Proteomics