Luís Filipe de Sepúlveda Silva Santos

Professor Auxiliar

Generic Bio

Luís Silva Santos. Natural de Coimbra (1978). Farmacêutico. Licenciado em Ciências Farmacêuticas pela Universidade de Coimbra (Faculdade de Farmácia) e Mestre em Patologia Experimental pela mesma Universidade (Faculdade de Medicina). Pós-graduações em Toxicologia Genética e Toxicogenómica (Universidade Nova de Lisboa) e em Bioética (Universidade Católica Portuguesa). Aguarda marcação de provas para obtenção do Grau de Doutor em Ciências Biomédicas pela Universidade do Porto (Instituto de Ciências Biomédicas Abel Salazar). Exerce funções docentes na Universidade Católica Portuguesa desde 2006, sendo actualmente o responsável pelas áreas disciplinares de Farmacologia, Toxicologia e Imunologia nos Cursos de Mestrado Integrado em Medicina Dentária e Licenciatura em Ciências Biomédicas. Integra o Conselho Pedagógico da Faculdade de Medicina Dentária da Universidade Católica Portuguesa. É investigador convidado Centro de Toxicogenómica e Saúde Humana (ToxOmics) da Faculdade de Ciências Médicas | NOVA Medical School da Universidade Nova de Lisboa, onde desenvolve trabalho de investigação na área da Medicina e Biomedicina, sub-áreas Farmacologia, Toxicologia e Diagnóstico Molecular. Conta com 9 artigos científicos publicados em revistas indexadas com revisão por pares, elaborados em colaboração com 32 outros co-autores e citados por 214 artigos indexados (h-index = 5; dados Scopus). 6 comunicações orais e 22 comunicações em painel (“poster”) em eventos científicos.

Outras

#079 Biomarcadores de genotoxicidade em imagiologia medico-dentária: uma revisão sistemática

Luís Filipe de Sepúlveda Silva Santos 2023. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Artigo

#146. miRNAs salivares como biomarcadores da Diabetes Mellitus tipo II

Maria José Serol de Brito Correia, Nuno Ricardo das Neves Rosa, Marlene Maria Tourais de Barros & Luís Filipe de Sepúlveda Silva Santos (with Alexandra Martins). 2016. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Outras

Avaliação da saúde oral numa população rural

Luís Filipe de Sepúlveda Silva Santos & Nélio Jorge Veiga (with Carla Barata). 2008. III Jornadas de Medicina Dentária da Universidade Católica Portuguesa
Outras

Biomarcadores de genotoxicidade em imagiologia medico-dentária

Luís Filipe de Sepúlveda Silva Santos (with Susana Alonso). 2023. XLIII Congresso Anual da Sociedade Portuguesa de Estomatologia e Medicina Dentária, Oeira, Portugal, 12/10/23
Outras

Cytogenetic changes in exfoliated oral mucosa cells as effect biomarkers in dental diagnostic imaging

Luís Filipe de Sepúlveda Silva Santos (with Susana Alonso). 2023. National Meeting of the Center for Interdisciplinary Research in Health (CIIS), Sintra, Portugal, 31/03/23
Outras

DNA damage in pathology staff occupationally exposed to formaldehyde

Luís Filipe de Sepúlveda Silva Santos (with João Paulo Teixeira). 2008. 99th Annual Meeting of the American Association for Cancer Research
Outras

DNA repair polymorphisms and oral cancer risk

Luís Filipe de Sepúlveda Silva Santos (with AM Marques). 2014. 7th Santorini Conference, Biologie Prospective , Santorini Island, Greece, 25/09/14
Outras

DNA repair SNPs as biomarkers of therapeutic response in oral cancer patients

Luís Filipe de Sepúlveda Silva Santos (with Bruna Mirahy). 2023. National Meeting of the Center for Interdisciplinary Research in Health (CIIS), Sintra, Portugal, 31/03/23
Outras

DNA repair SNPs as genetic modulators of individual susceptibility to differentiated thyroid cancer and response to radioiodine therapy

Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2021.
Outras

DNA repair SNPs as modulators of response to cancer radiotherapy

Luís Filipe de Sepúlveda Silva Santos (with A. M. Marques). 2015. Drug Metabolism and Personalized Therapy
Outras

Estudo biomorfológico do intestino grosso na administração experimental de cerveja

Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2006.
Outras

Evaluation of formaldehyde exposure in the work environment

Luís Filipe de Sepúlveda Silva Santos (with S. Costa). 2014. 7th Santorini Conference, Biologie Prospective , Santorini Island, Greece, 25/09/14
Outras

Excision repair SNPs may influence the extent of DNA damage from radioiodine therapy in lymphocytes from thyroid cancer patients

Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2023. National Meeting of the Center for Interdisciplinary Research in Health (CIIS), Sintra, Portugal, 31/03/23
Outras

Farmacología de la inmunidad

Luís Filipe de Sepúlveda Silva Santos (with Silva Santos, Luís). 2011.
Livro

Farmacología del crecimiento neoplásico

Luís Filipe de Sepúlveda Silva Santos (with Luís Filipe de Sepúlveda Silva Santos). 2011.
Artigo

Genetic effects and biotoxicity monitoring of occupational styrene exposure

Luís Filipe de Sepúlveda Silva Santos (with Rueff, J.). 2009. Clinica Chimica Acta
Artigo

Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde

Luís Filipe de Sepúlveda Silva Santos (with Costa, S.). 2008. Toxicology
Outras

Human Genome Project: a window of opportunity

Luís Filipe de Sepúlveda Silva Santos (with Luís Filipe de Sepúlveda Silva Santos). 2002. 48th IPSF World Congress
Outras

Identification of miRNAs with potential utility as salivary biomarkers for type II diabetes

Nuno Ricardo das Neves Rosa & Luís Filipe de Sepúlveda Silva Santos (with A. Martins). 2016. Clinical Chemistry and Laboratory Medicine
Outras

In silico analysis of non-synonymous SNPs in toxicogenomic studies

Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2013. Second International Conference on Occupational and Environmental Toxicology, Porto, Portugal, 16/09/13
Outras

In silico analysis of non-synonymous SNPs in toxicogenomic studies: impact of genetic variation on the FANC DNA repair pathway and susceptibility to DPC- and ICL-inducing chemical agents

Luís Filipe de Sepúlveda Silva Santos (with Luís Filipe de Sepúlveda Silva Santos). 2013. International Conference on Occupational & Environmental Toxicology (ICOETox 2013)
Outras

In silico analysis of SNPs in pharmacogenomic studies: predictive functional analysis of SLC5A5 gene variants and potential impact on radioactive iodine (131-I) therapy response

Luís Filipe de Sepúlveda Silva Santos (with Silva Santos, Luís). 2013. Second ESPT Conference “Pharmacogenomics: From Cell to Clinic”
Outras

In silico analysis of SNPs in pharmacogenomic studies: predictive functional analysis of SLC5A5 gene variants and potential impact on radioactive iodine (131-I) therapy response

Luís Filipe de Sepúlveda Silva Santos (with Luís Filipe de Sepúlveda Silva Santos). 2013. Second ESPT Conference ¿Pharmacogenomics: From Cell to Clinic¿
Artigo

Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde

Luís Filipe de Sepúlveda Silva Santos (with Costa, S.). 2015. Mutagenesis
Artigo

Micronuclei Formation upon Radioiodine Therapy for Well-Differentiated Thyroid Cancer: The Influence of DNA Repair Genes Variants

Luís Filipe de Sepúlveda Silva Santos (with Luís S. Santos). 2020. Genes
Outras

miRNAs as potential salivary biomarkers in periodontitis

Nuno Ricardo das Neves Rosa & Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2016. Clinical Chemistry and Laboratory Medicine
Outras

miRNAs como biomarcadores

Nuno Ricardo das Neves Rosa & Luís Filipe de Sepúlveda Silva Santos (with S Rei). 2015. I Jornadas Científicas da Primavera, Viseu, Portugal, 20/03/15
Outras

MiRNAs salivares como biomarcadores da diabetes Mellitus tipo II (DMTH)

Artigo

Mismatch repair single nucleotide polymorphisms and thyroid cancer susceptibility

Luís Filipe de Sepúlveda Silva Santos (with Santos, L.S.). 2018. Oncology Letters
Outras

Mismatch repair SNPs and thyroid cancer susceptibility

Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2015. Drug Metabolism and Personalized Therapy
Artigo

Newly identified synergy between clopidogrel and calcium-channel blockers for blood pressure regulation possibly involves CYP2C19 rs4244285

Luís Filipe de Sepúlveda Silva Santos (with Stathopoulou, M.G.). 2013. International Journal of Cardiology
Capítulo de Livro

Optimización de la adecuación terapéutica en pacientes polimedicados

Luís Filipe de Sepúlveda Silva Santos (with Luís Filipe de Sepúlveda Silva Santos). 2011. Polimedicación y Salud: Estrategias para la adecuación terapéutica
Outras

Personalized cancer radiotherapy

Luís Filipe de Sepúlveda Silva Santos (with AM Marques). 2016. Clinical Chemistry and Laboratory Medicine
Artigo

Polymorphisms in base excision repair genes and thyroid cancer risk

Luís Filipe de Sepúlveda Silva Santos (with Santos, L.S.). 2012. Oncology Reports
Outras

Polymorphisms in DNA repair genes and non-familiar thyroid cancer risk

Luís Filipe de Sepúlveda Silva Santos (with BC Gomes). 2010. AACR Special Conference in Cancer Research , Miami, United States, 6/06/10
Outras

Polymorphisms in DNA repair genes and non-familiar thyroid cancer risk

Luís Filipe de Sepúlveda Silva Santos (with Bruno Gomes). 2010. AACR Special Conference in Cancer Research - The Future of Molecular Epidemiology: New Tools, Biomarkers, and Opportunities
Outras

Pontos no CIIS | SalivaTec

Luís Filipe de Sepúlveda Silva Santos (with Ana Sofia Duarte). 2022.
Outras

Synergy between clopidogrel and calcium-channel blockers for blood pressure regulation possibly involves CYP2C19 polymorphism

Luís Filipe de Sepúlveda Silva Santos (with Maria G. Stathopoulou). 2013. Drug Metabolism and Personalized Therapy
Outras

The potential contribution of DNA repair SNPs to thyroid cancer susceptibility

Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2016. 2º Simpósio de Ciências e Tecnologias da Vida e da Saúde, Porto, Portugal, 30/09/16
Outras

The potential contribution of SNP-SNP interactions within the DNA mismatch repair pathway to thyroid cancer susceptibility

Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2017. Fourth ESPT Conference , Catania, Italy, 4/10/17
Outras

The potential impact of DNA repair SNPs on DNA damage levels of lymphocytes from 131I-treated thyroid cancer patients

Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2017. Fourth ESPT Conference , Catania, Italy, 4/10/17
Artigo

The role of CCNH Val270Ala (rs2230641) and other nucleotide excision repair polymorphisms in individual susceptibility to well-differentiated thyroid cancer

Luís Filipe de Sepúlveda Silva Santos (with Santos, L.S.). 2013. Oncology Reports
Outras

The role of CCNH Val270Ala and other nucleotide excision repair polymorphisms on individual susceptibility towards thyroid cancer

Luís Filipe de Sepúlveda Silva Santos (with Silva Santos, Luís). 2012. 6th Santorini Conference Biologie Prospective "Systems Biology and Personalized Health Science and Translation"
Outras

Thyroid Cancer: The Quest for Genetic Susceptibility Involving DNA Repair Genes

Luís Filipe de Sepúlveda Silva Santos (with Santos, Luis S.). 2019. 2º Encontro de Ciência da NOVA, Lisboa, Portugal, 18/09/19
Artigo

Thyroid Cancer: The Quest for Genetic Susceptibility Involving DNA Repair Genes